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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NHSL1 All Species: 4.55
Human Site: S544 Identified Species: 12.5
UniProt: Q5SYE7 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.13
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5SYE7 NP_065197.1 1610 170668 S544 V D G K S E S S Y S G G G G H
Chimpanzee Pan troglodytes XP_001171693 1611 170460 S539 S T P T S N M S S C S L D Q T
Rhesus Macaque Macaca mulatta XP_001095123 1561 165521 H525 R A S P L K P H V A T P G Y S
Dog Lupus familis XP_533424 1576 166550 P528 L K A H L T T P G Y S T P G S
Cat Felis silvestris
Mouse Mus musculus Q8CAF4 1587 169401 S536 P S D V D G K S E C S Y S G D
Rat Rattus norvegicus XP_002725496 1593 169646 S540 V D G K S E C S S S G D R G C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509254 1768 188530 E536 Q D S D G R S E S S G S G D R
Chicken Gallus gallus XP_419717 1652 178098 G549 R S E S S Y S G E R T Q G V V
Frog Xenopus laevis NP_001088582 1443 160071 S407 S R M A D S G S C D I S S N S
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 94.8 91.2 74.7 N.A. 75.9 75.8 N.A. 57.9 57.8 21.7 N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 95.9 93.1 79.8 N.A. 82.5 81.9 N.A. 66.7 69.4 38 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 13.3 6.6 6.6 N.A. 13.3 66.6 N.A. 33.3 20 6.6 N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 20 20 N.A. 13.3 66.6 N.A. 33.3 20 6.6 N.A. N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 12 12 0 0 0 0 0 12 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 12 0 12 23 0 0 0 0 12 % C
% Asp: 0 34 12 12 23 0 0 0 0 12 0 12 12 12 12 % D
% Glu: 0 0 12 0 0 23 0 12 23 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 23 0 12 12 12 12 12 0 34 12 45 45 0 % G
% His: 0 0 0 12 0 0 0 12 0 0 0 0 0 0 12 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % I
% Lys: 0 12 0 23 0 12 12 0 0 0 0 0 0 0 0 % K
% Leu: 12 0 0 0 23 0 0 0 0 0 0 12 0 0 0 % L
% Met: 0 0 12 0 0 0 12 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 12 0 0 0 0 0 0 0 12 0 % N
% Pro: 12 0 12 12 0 0 12 12 0 0 0 12 12 0 0 % P
% Gln: 12 0 0 0 0 0 0 0 0 0 0 12 0 12 0 % Q
% Arg: 23 12 0 0 0 12 0 0 0 12 0 0 12 0 12 % R
% Ser: 23 23 23 12 45 12 34 56 34 34 34 23 23 0 34 % S
% Thr: 0 12 0 12 0 12 12 0 0 0 23 12 0 0 12 % T
% Val: 23 0 0 12 0 0 0 0 12 0 0 0 0 12 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 12 0 0 12 12 0 12 0 12 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _